Migliorino was born in Cleveland Ohio and grew up in a Southside Chicago suburb. Her BFA is from the School of the Art Institute of Chicago and MFA is from the University of Minnesota. She teaches at Anoka-Ramsey Community College as a Photography professor. Migliorino received numerous grants from the Jerome Foundation, several Minnesota State Arts Board grants and various exhibition prizes. Her work is in the permanent collection of the Walker Art Center and the Weisman Museum in Minneapolis. She has exhibited internationally for over 30 years.